Introductions to Biomaterials

Written and produced by Xuchen Liu

University of Sheffield

January 16, 2023

Let's combine the problem with the advanced example in a real, living environment: You’re trying to implant the cardiovascular stent shown below into your patient.

As a bioengineer or a materials scientist in the future, our work will have a close connection with doctors, and in the operations clinicians will implant our masterpiece into patients, thereby healing patients and that’s realizing our value.

Let’s explore some problems and natures together.

Figure 1: Bioabsorbable magnesium stent (BIOTRONIK, Berlin, Germany) (A) after expansion, (B) before expansion, and (C) in an electron microscopy magnification. (Chng et al., 2012)

Jialiang Wang 12/31/21 Jialiang Wang 12/31/21

Cells adhesion and their behaviours

When we implant this stent into a patient, the cells will adhere to the biomaterial.

Jialiang Wang 12/30/21 Jialiang Wang 12/30/21

Cells communication following the implantation

When cells touch the stent, there are a lot of physical and chemical reactions happen.

Jialiang Wang 12/29/21 Jialiang Wang 12/29/21

Immune system’s contribution to the body’s response to material / how do materials interact with the blood

As foreign objects, foreign body reaction (FBR) is undoubtedly cannot be avoided to talk about.

Jialiang Wang 12/28/21 Jialiang Wang 12/28/21

Why should test our biomaterial and how to test?

Firstly, we have to introduce a concept called biocompatibility.

Jialiang Wang 12/27/21 Jialiang Wang 12/27/21

Adverse effects/ how can they be avoided?

The risk of adverse effects of implanted biomaterials is greatly increased.

Reference

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